Structural basis of sequence-specific collagen recognition by SPARC
نویسندگان
چکیده
منابع مشابه
Structural basis of sequence-specific collagen recognition by SPARC.
Protein interactions with the collagen triple helix play a critical role in collagen fibril formation, cell adhesion, and signaling. However, structural insight into sequence-specific collagen recognition is limited to an integrin-peptide complex. A GVMGFO motif in fibrillar collagens (O denotes 4-hydroxyproline) binds 3 unrelated proteins: von Willebrand factor (VWF), discoidin domain receptor...
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and ␣X) contain an additional domain (" A " or " I ") that is inserted into the head region, where it plays a central role in ligand binding: thus, recombinant I domains reca-pitulate many of the ligand-binding properties of the The first crystal struc-United Kingdom † Department of Biochemistry ture of an I domain showed that it adopts the " dinucleo-tide-binding " fold, with a central mostly ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0808452105